Research Group
Selmi Group
Clinical Autoimmunity and Metabolism Lab
Selmi's Lab is dedicated to organ-specific and systemic autoimmune and chronic inflammatory diseases, including the clinical epidemiology and pathogenetic mechanisms of autoimmune liver disease, connective tissue disease (particularly systemic sclerosis), and psoriatic arthritis.
Main Research Interests
Biomarkers for autoimmune and chronic inflammatory diseases, particularly novel serum autoantibodies and epigenetic changes. This interest is mirrored by the collection over the years of series of monozygotic twins both discordant and concordant for paradigmatic conditions (i.e. psoriasis and psoriatic arthritis, systemic sclerosis, autoimmune liver disease, inflammatory bowel disease) and by the use of immunoprecipitation and epigenome approaches.
Post-translational modifications of established and proposed autoantigens in rheumatoid arthritis and in psoriatic disease.
Clinical epidemiology of autoimmunity and chronic inflammatory disease with large population-based case-finding studies for serum autoantibodies and the analysys of real-life administrative databases.
Selected publications
An Italian Disease-Based Registry of Axial and Peripheral Spondyloarthritis: The SIRENA Study.
The JANUS of chronic inflammatory and autoimmune diseases onset during COVID-19 – A systematic review of the literature.
Serum IFI16 and anti-IFI16 antibodies in psoriatic arthritis.
The role of epigenetics and immunological imbalance in the etiopathogenesis of psoriasis and psoriatic arthritis.
Safety issues and recommendations for successful pregnancy outcome in systemic lupus erythematosus.
Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex.
The long and latent road to autoimmunity.
Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept.
Timing of onset affects arthritis presentation pattern in antisyntethase syndrome.
Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis.
Lessons learned from twins in autoimmune and chronic inflammatory diseases.
Eight-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Spondyloarthritis: A Multicenter Retrospective Analysis.
Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study.
The Immune Response and the Pathogenesis of Idiopathic Inflammatory Myositis: a Critical Review.
Myositis-specific autoantibodies and their association with malignancy in Italian patients with polymyositis and dermatomyositis.
Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)-DR4(+) monozygotic twins discordant for rheumatoid arthritis.
Biomarkers in psoriatic arthritis: a systematic literature review.
Serum antinuclear and extractable nuclear antigen antibody prevalence and associated morbidity and mortality in the general population over 15 years.
Interleukin-17 and innate immunity in infections and chronic inflammation.
Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Group members
