Team
CNR Neuroscience Research Team
The CNR research groups investigate the mechanisms underlying neurological and neurodevelopmental disorders, with a particular focus on the role of the immune system. In particular, the researchers study how maternal immune activation affects the development of synaptic circuits in offspring, emphasizing the contribution of immune molecules released by astrocytes and microglia. Additionally, they explore the inflammatory profile of stroke patients to support the design of personalized rehabilitation strategies. This interdisciplinary approach bridges neuroimmunology and translational neuroscience to advance understanding and treatment of brain disorders.
Selected publications
Brain Behav Immun
Loss of interleukin 1 signaling causes impairment of microglia- mediated synapse elimination and autistic-like behaviour in mice.
J Clin Epidemiol
A multicenter prospective study validated a nomogram to predict individual risk of dependence in ambulation after rehabilitation.
Sci Rep
Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus.
EMBO J
Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring.
Commun Biol
Brain sex-dependent alterations after prolonged high fat diet exposure in mice.
Cell Mol Life Sci
Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors.
Nat Commun
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
JCI Insight
The DNA repair protein ATM as a target in autism spectrum disorder.
EMBO J
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Biol Psychiatry
Maternal Immune Activation Delays Excitatory-to-Inhibitory Gamma-Aminobutyric Acid Switch in Offspring.
Team members
