The Xenium platform enables imaging‑based in situ spatial transcriptomics with subcellular resolution. Using padlock-probe and rolling-circle amplification chemistry, Xenium achieves exceptional sensitivity and specificity, even in challenging FFPE or frozen tissue samples. It supports pre-designed gene panels from tens to thousands of genes or fully customizable panels, empowering large-scale, hypothesis-driven spatial studies. With an intuitive instrument workflow, robust fluidics, onboard analysis, and advanced data visualization, Xenium allows HuGE to perform  spatial experiments  at single cell resolution efficiently, reproducibly, and linking molecular detail to tissue context.