Research Group
Selmi Group
Clinical Autoimmunity and Metabolism Lab
Selmi's Lab is dedicated to organ-specific and systemic autoimmune and chronic inflammatory diseases, including the clinical epidemiology and pathogenetic mechanisms of autoimmune liver disease, connective tissue disease (particularly systemic sclerosis), and psoriatic arthritis. Its projects have been funded, among others, by the National Institutes of Health the American Liver Foundation and the American Scleroderma Foundation.
Main Research Interests
Biomarkers for autoimmune and chronic inflammatory diseases, particularly novel serum autoantibodies and epigenetic changes. This interest is mirrored by the collection over the years of series of monozygotic twins both discordant and concordant for paradigmatic conditions (i.e. psoriasis and psoriatic arthritis, systemic sclerosis, autoimmune liver disease, inflammatory bowel disease) and by the use of immunoprecipitation and epigenome approaches.
Post-translational modifications of established and proposed autoantigens in rheumatoid arthritis and in psoriatic disease
Clinical epidemiology of autoimmunity and chronic inflammatory disease with large population-based case-finding studies for serum autoantibodies and the analysys of real-life administrative databases.
Selected publications
Safety issues and recommendations for successful pregnancy outcome in systemic lupus erythematosus.
Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex.
The long and latent road to autoimmunity.
Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept.
Timing of onset affects arthritis presentation pattern in antisyntethase syndrome.
Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis.
Lessons learned from twins in autoimmune and chronic inflammatory diseases.
Eight-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Spondyloarthritis: A Multicenter Retrospective Analysis.
Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study.
The Immune Response and the Pathogenesis of Idiopathic Inflammatory Myositis: a Critical Review.
Myositis-specific autoantibodies and their association with malignancy in Italian patients with polymyositis and dermatomyositis.
Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)-DR4(+) monozygotic twins discordant for rheumatoid arthritis.
Biomarkers in psoriatic arthritis: a systematic literature review.
Serum antinuclear and extractable nuclear antigen antibody prevalence and associated morbidity and mortality in the general population over 15 years.
Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome: Results From an International Retrospective Multicenter Study.
Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27-positive ankylosing spondylitis.
Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation: the case of zoledronic acid-induced acute phase reaction.
Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis.
Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop.
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Overcoming a “probable” diagnosis in antimitochondrial antibody negative primary biliary cirrhosis: study of 100 sera and review of the literature.
The epigenetics of autoimmunity.
Prevalence of hepatitis C serum antibody in autoimmune diseases.
Group members
