Dr Cristina Sobacchi graduated in Pharmaceutical Chemistry and Technologies at the University of Milan in 1998, with a Training in Molecular Biology. She is Primo Ricercatore CNR since 2022. Her main interest are the molecular and cellular mechanisms involved in bone pathophysiology. She contributed to identifying several genes responsible for human osteopetrosis, and for this has been involved in the definition and periodical review of the Consensus Guidelines for diagnosis, therapy and follow-up of Osteopetrosis, on behalf of the ESID and the European Bone Marrow Transplantation-Inborn Error Working Party (EBMT-IEWP).
She has also carried out preclinical studies aimed at the development of new therapies for osteopetrosis, by using pharmacological, cell-based and gene therapy approaches. Specifically, she has a longstanding interest in the investigation of bone pathophysiological mechanisms and therapies related to RANKL cytokine. Additional recent topics of her research are the role of oxidative stress in diverse bone pathophysiological conditions, particularly focusing on the DPP3/Keap1/Nrf2 antioxidant pathway and related molecular and cellular events; and the mechanisms underlying resistance/sensitivity to Staphylococcus aureus bone infection.
She is a Member of the European Calcified Tissue Society (ECTS), where she has been actively serving in different Committees (member of the Training Committee 2012-2017 and currently chair of the ECTS PhD Training Action Group; ECTS Global Outreach/IFMRS Action Group since 2018), and Member of the Forum in Bone and Mineral Research. She received the ECTS Young Investigator Award in 2007 and the ECTS/ABBH Ian Boyle Award in 2009. She has been invited speaker to several National and International Scientific Meetings in the field.
She is coauthor of 81 papers in peer-reviewed journals in which she features mainly as first or last author (h index: 28; Source: Scopus), and 3 Book Chapters.