Marianna Paulis graduated in Biological Sciences in 2000 at the University of Pavia, where she also obtained a PhD in Genetic and Biomolecular Sciences in 2004. During her PhD, she attended for 3 years the Advanced School for Integrated Formation (SAFI) established by the University School for Advanced Studies (IUSS) of Pavia and achieved the certificate of advanced post-graduate education in 2004. Since 2006 she has been working at the National Research Council (CNR) of Milan with a post-doctoral position and in 2007 her laboratory moved to the Humanitas Research Hospital. In 2015, she received a tenured position as Researcher at the Institute of Genetic and Biomedical Research (IRGB) of the CNR based in Milan.

She has a long-lasting research experience and expertise in the field of classical and molecular cytogenetic of mammalian cells and years of experience in mouse and human pluripotent stem cells (both ESCs and iPSCs). Her main interest is in the investigation of gene therapy approaches for genome disorders due to chromosomal abnormalities. Currently, her main activity is the generation and corrections of iPSCs from patients affected by genetic diseases and in iPSC differentiation with particular interest in the generation of iPSC-derived human organoids to help bridge gap between laboratory study and animal models. Her laboratory currently counts two phD students and a technician with experience in iPSCs, in molecular biology technics and CRISPR/Cas9 technology. She received competitive grants and contracts from national and european agencies, as the Italian Ministry of Education University and Research and the European Community.