My research centers on mitochondrial dynamics — specifically how changes in mitochondrial fusion contribute to cardiovascular and neurodegenerative diseases. My goal is to better understand these underlying mechanisms so we can develop targeted therapies for conditions that are currently incurable.
My scientific journey began in Naples, Italy, where I earned my Ph.D. in Clinical Pathology and Physiology from the University of Naples Federico II in 2016. During my doctoral studies, I explored the role of G-protein-coupled receptor kinase 2 (GRK2) in promoting mitochondrial recovery following exposure to ionizing radiation.
I later continued my research at the Washington University School of Medicine in St. Louis. There, I focused on Charcot-Marie-Tooth Type 2A (CMT2A), a severe hereditary neurological disorder caused by mutations in the Mitofusin2 gene. This work has been featured in journals such as Nature, Science, and eLife.
Currently, at Humanitas is investigating mitochondrial fusion defects in the context of heart failure. A key focus is testing Mitofusin agonist compounds as a possible treatment for diseases linked to impaired mitochondrial dynamics. I’m also studying human genetic variants associated with these disorders, with the long-term aim of advancing personalized medicine approaches.
My work is driven by a strong belief in the therapeutic potential of targeting mitochondrial health, and I remain committed to finding novel strategies that can truly improve patient outcomes.