Technology Platforms

Metabolomics

Metabolomics

Giuseppe Martano

Head of Facility

Metabolomics

Lavinia Morosi

Head of facility
Staff scientist

The Metabolomics Unit provides untargeted and targeted analysis of small molecules (metabolites, lipids, drugs and peptides) basing on mass spectrometry. The unit develops and validates analytical methods suitable for clinical and preclinical analysis in different biological samples.

Metabolomic studies can provide a global view of metabolism and thereby improve our understanding of the underlying biology. Moreover, metabolic fingerprints generated by metabolomics can be efficiently used in clinical and pre-clinical studies as a powerful tool in biomarker discovery and the development of personalized medicine.

Why contact us

  • Biomarker discovery
  • De-novo compound identification from biological specimens
  • Pharmacokinetics analysis in clinical and pre-clinical samples
  • Metabolic dynamic labelling profile and isotopically stationary and non-stationary flux analysis
  • Spatial metabolomics
  • 3D drug/metabolite tissue distribution

Services provided

  • Global Metabolomics analysis
  • Lipidomics
  • Targeted analysis (Quantitative, semi-quantitative)
  • De-novo compound identification
  • Imaging Mass Spectrometry (Untargeted and Targeted)
  • Data analysis and post-data analysis

The Metabolomics Unit staff consists of highly qualified and specialized personnel with a wide range of expertise in mass spectrometry from untargeted metabolomics to pharmacokinetics particularly focused on the continuous evolution of the techniques and methodologies to answer the most complex scientific questions.

Get in touch

For more information and collaborations write to metabolomics@humanitasresearch.it

Equipment

The Metabolomics Unit in Humanitas is equipped with cutting-edge instruments providing unprecedented sensitivity, accuracy and scalability:

  • Mass spectrometers
  • Chromatography
  • Ion sources.

The instruments are available in several configurations in order to adapt the analytical workflow to biological aims and limitations.

Machinery

We use high end technology of the latest industry standards

Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer
Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer
Orbitrap Exploris™ 120 Mass Spectrometer
Orbitrap Exploris™ 120 Mass Spectrometer
TSQ Altis™ Triple Quadrupole Mass Spectrometer
TSQ Altis™ Triple Quadrupole Mass Spectrometer
Vanquish™ Flex UHPLC Systems
Vanquish™ Flex UHPLC Systems
Vanquish™ Core HPLC Systems
Vanquish™ Core HPLC Systems
UltiMate™ 3000 RSLCnano System
UltiMate™ 3000 RSLCnano System
AP/MALDI (ng) UHR MassTech
AP/MALDI (ng) UHR MassTech
Nanospray Flex™ Ion Source
Nanospray Flex™ Ion Source
OptaMax NG Ion Source
OptaMax NG Ion Source

Selected publications

Morosi L
Brief Bioinform
MSIpixel: a fully automated pipeline for compound annotation and quantitation in mass spectrometry imaging experiments.

Staff

Metabolomics
Giuseppe Martano

Head of Facility

Metabolomics
Lavinia Morosi

Head of facility
Staff scientist

Metabolomics
Sara Timo

Technician